5 Amino 1MQ
A selective NNMT inhibitor that promotes fat cell metabolism by blocking a key enzyme involved in energy storage, researched for obesity treatment and metabolic reprogramming of white adipose tissue. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
5-Amino-1-methylquinolinium (5-Amino-1MQ) inhibits nicotinamide N-methyltransferase (NNMT), an enzyme regulating cellular metabolism and energy homeostasis, promoting a shift from energy storage toward expenditure.
Research Highlights
1. NNMT Inhibition โ Blocks methylation of nicotinamide, preserving methyl groups for epigenetic modifications.
2. Adipose Metabolism โ Increases NAD+ and SAM in adipocytes, enhancing mitochondrial activity and reducing lipid accumulation without affecting food intake.
3. Obesity Research โ Reduced body weight and fat mass in diet-induced obesity models while improving glucose tolerance.
4. Metabolic Reprogramming โ Modulates NAD+ salvage pathway and methylation balance, potentially reversing pro-obesity gene expression.
5. Cancer โ NNMT overexpression in several cancer types; inhibition shows anti-proliferative effects.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
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