Epithalon

Epithalon (Ala-Glu-Asp-Gly) is a short synthetic tetrapeptide first discovered in the late 1980s by Prof. Vladimir Khavinson. As a derivative of epithalamine, it has attracted research interest for telomerase activation and anti-aging properties.

Research Highlights

1. Anti-Aging and Telomerase — Reduced mortality by 52% in fruit flies/rats and 27% in mice. Induced telomerase activity in human somatic cells.

2. DNA and Gene Expression — Interacts with promoter regions of CD5, IL-2, MMP2, and Tram1 genes. Increases interferon gamma expression in aging lymphocytes.

3. Skin Cell Regeneration — Stimulated fibroblast proliferation by 29-45% in young and old rats. Reduces caspase-3 activity.

4. Tumor Growth Modulation — Inhibited spontaneous tumors, prevented metastasis in mice without toxic effects.

5. Melatonin Regulation — Stimulates AANAT and pCREB expression. Restored melatonin production in aged monkeys.

6. Retinal Protection — Improved retinal condition in 90% of retinitis pigmentosa cases.

References available upon request.

The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.