Mots-C
A mitochondrial-derived peptide that translocates to the nucleus during metabolic stress, enhancing glucose metabolism, insulin sensitivity, and bone health through AMPK-dependent mechanisms. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide discovered around 2012 at USC. It represents a novel form of mitochondrial-nuclear communication, regulating nuclear gene expression during metabolic stress.
Research Highlights
1. Muscle Metabolism — Enhances glucose uptake via AMPK activation independently of insulin pathway.
2. Fat Metabolism — Mitigated obesity and insulin resistance in ovariectomized mice. Reduced sphingolipid and monoacylglycerol metabolism.
3. Insulin Sensitivity — Plasma levels correlate with insulin sensitivity in lean individuals. Enhanced beta-oxidation.
4. Bone Health — Promotes type I collagen synthesis via TGF-β/SMAD pathway and osteogenic differentiation.
5. Longevity — Specific gene variant in Northeast Asian populations associated with exceptional longevity.
6. Cardiovascular — Lower levels correlate with endothelial dysfunction. Pretreatment improved vascular responsiveness.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
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