GHK-Cu

What is GHK-Cu?

GHK-Cu is a tripeptide that occurs naturally in human plasma, saliva, and urine. Its concentration in plasma declines with age. The molecule binds copper(II) with high affinity and a substantial body of preclinical literature has examined its activity in fibroblast culture, wound models, and skin biology.

Mechanism of action (preclinical evidence)

GHK-Cu has been reported to up-regulate genes involved in extracellular matrix remodelling, antioxidant defence, and inflammation modulation. Effects observed in fibroblast culture include increased synthesis of collagen, elastin, and glycosaminoglycans, and modulation of metalloproteinase activity. The copper-binding capacity is implicated in many of the observed activities.

Research applications

• Dermal fibroblast culture studies (collagen synthesis)
• Wound healing models (full-thickness skin injury)
• Hair follicle biology and dermal papilla cultures
• Anti-oxidant and gene-expression modulation in vitro
• Cosmetic formulation research

Storage and handling

Store lyophilised GHK-Cu at -20 °C. The copper complex is sensitive to light and oxidation — keep vials sealed and protected. Reconstituted solutions should be used promptly or stored short-term at 2-8 °C in the dark.

Regulatory status

GHK-Cu has been used historically as a cosmetic ingredient under tripeptide-1 nomenclature, but research-grade material is supplied for laboratory work only. Not approved as a drug by the FDA or EMA.