KPV

What is KPV?

KPV is a synthetic tripeptide corresponding to the C-terminal three residues of α-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV retains a substantial portion of α-MSH's anti-inflammatory activity in preclinical systems. It has been investigated as a research probe for melanocortin receptor-independent immunomodulation.

Mechanism of action (preclinical evidence)

KPV is reported to inhibit NF-κB signaling, reduce pro-inflammatory cytokine release (TNF-α, IL-6), and modulate mast cell activation in cell culture and animal models. Unlike full-length α-MSH, KPV's effects appear to be largely independent of melanocortin receptors, suggesting an intracellular mechanism. The peptide also shows direct effects on intestinal epithelial cells, supporting its use in gut barrier research.

Research applications

• Inflammatory bowel disease (IBD) models in rodents
• Atopic dermatitis and skin inflammation cell culture
• Mast cell biology and degranulation studies
• Intestinal epithelial barrier integrity research
• Comparative studies with α-MSH and other melanocortin peptides

Storage and handling

Lyophilised KPV is stable at -20 °C in a sealed vial protected from light. Tripeptides are relatively stable in aqueous solution; aliquot reconstituted material to avoid freeze-thaw degradation.

Regulatory status

KPV is not an approved drug in any major regulatory framework. Supplied by Peptra Labs strictly for laboratory research.