Posts by Peptra Labs Research
Retatrutide + Cagrilintide: Rat Study Beats Singles
Retatrutide plus cagrilintide outperformed matched monotherapies for weight and metabolic measures in obese male rats.
GLP-1 Receptor Agonists: One Circuit, Two Effects
GLP-1 receptor agonists engaged one brainstem circuit for both reduced feeding and aversion in a new preclinical study.
Tirzepatide: 22,104 Matched Bariatric-Surgery Patients
Tirzepatide or GLP-1RA use before bariatric surgery was associated with fewer 90-day cardiorenal events in 22,104 matched patients.
Tirzepatide: 415 Matched Knee-Arthroplasty Pairs
Tirzepatide and semaglutide showed similar 90- and 180-day postoperative outcomes in 415 matched pairs undergoing knee arthroplasty.
GLP-1 Receptor Agonists: 44 Adolescent Records
GLP-1 receptor agonists were not linked to higher short-term suicidality scores in a small retrospective review of 44 adolescents.
Tirzepatide vs Semaglutide: 8,176 Asthma Pairs
Tirzepatide and semaglutide had similar recorded asthma-exacerbation risk in 8,176 matched pairs, while SABA use differed modestly.
GLP-1 and Lean Mass: 60 Studies, 1.25m People
GLP-1 evidence from 60 studies found lower lean mass, but no significant bone or joint effect and low certainty for muscle implications.
Tirzepatide and Cold: No Added Loss in Mice
Tirzepatide and intermittent cold exposure improved separate measures in obese mice, but the combination did not add weight loss.
Tirzepatide in IBD: 3,042 Matched Pairs
Tirzepatide in IBD was associated with fewer IV steroid events in 3,042 matched pairs, but the retrospective design cannot establish cause.
Nanocarriers of 4 to 30 nm Cut Fat, Not Food Intake
Nanocarriers delivering an anti-inflammatory drug to fat tissue reduced body fat in obese mice with no change in how much the animals ate.