Tag Archives: target trial emulation
Semaglutide and NAION: 2.33 Relative, 0.16 Points Absolute
Semaglutide initiators had 2.33 times the NAION risk of SGLT2 users in 102,361 veterans. The absolute difference was 0.16 percentage points.
GLP-1 in Serious Mental Illness: 764,115 Matched Pairs
GLP-1 initiation was linked to lower four-year mortality than SGLT2 inhibitors in serious mental illness, and the absolute gap was larger there.
GLP-1 Below BMI 27: Benefit With Little Weight to Lose
GLP-1 receptor agonists cut coded heart failure in type 2 diabetes with a BMI under 27, where there is almost no weight left to lose.
Tirzepatide vs Semaglutide: Liver Outcomes Are Level
Tirzepatide dropped more BMI than semaglutide over 17 months, and hard liver outcomes came out identical: 4.05 versus 4.04 events per 1000 person-years.