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Tirzepatide and Semaglutide: 15-20% in a New Review
Tirzepatide and semaglutide give 15 to 20 percent mean weight loss over 12 to 18 months, a new narrative review reports, with wider gains.
Peptide Stability: Polysorbate 80 Sped Up Aggregation
Peptide stability fell rather than rose with surfactants. Polysorbate 80 drove faster liraglutide aggregation, and glucagon fibrillated regardless.
Semaglutide ESSENCE Subgroup: Why 116 Patients Is Too Few
Semaglutide resolved steatohepatitis in 63.1% of 116 Japanese ESSENCE participants. The fibrosis endpoint could not separate at that sample size.