News
Semaglutide Extended Lifespan in Mice Treated at 20 Months
Semaglutide started at 20 months extended lifespan in female mice and beat matched calorie restriction on memory, exploration and glucose control.
Retatrutide Bought Online: A Type 1 Diabetes Case Report
Retatrutide bought online preceded ketonaemia of 4.3 mmol/L in a man with type 1 diabetes. Stool grew Shigella, and causation stays unresolved.
Semaglutide: 24 Outcomes, 63,215 Adults, One Split
Semaglutide was linked to lower neuropsychiatric event rates in 63,215 adults, and the authors report the association ran independent of weight loss.
GLP-1 and Reflux: The Same Signal in 3 Countries
GLP-1 receptor agonists drew a reflux signal in US, Japanese and Canadian databases, with reporting odds ratios running from 2.83 to 4.76.
Peptide Stability: Polysorbate 80 Sped Up Aggregation
Peptide stability fell rather than rose with surfactants. Polysorbate 80 drove faster liraglutide aggregation, and glucagon fibrillated regardless.
Tirzepatide Regain: 1.04 kg a Month, 15 Months Modelled
Tirzepatide and semaglutide users regained 1.04 kg a month after stopping. The 15 months to baseline is an extrapolation, not an observation.
Retatrutide at 22.1%: What the Table Does Not Show
Retatrutide reached 22.1% placebo-subtracted weight loss in an Annals review of 38 trials, where heterogeneity blocked quantitative synthesis.
MOTS-c in Kidney Failure: 160 Adults, Wasting Not Linked
MOTS-c was inversely associated with glycoxidative stress in 160 adults with kidney failure, while protein-energy wasting showed no association at all.
Semaglutide in the Spinal Cord: Enkephalin Does the Work
Semaglutide given intrathecally eased burn pain in mice, and blocking enkephalin or the delta-opioid receptor removed the effect, the authors report.
GLP-1 and Atrial Fibrillation: 10 Reviews, Same Trials
GLP-1 and atrial fibrillation has ten meta-analyses behind it. An umbrella review rated none above low confidence and found the trials heavily shared.