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5-Amino-1MQ

5-Amino-1-methylquinolinium iodide (NNMT inhibitor)

Small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), used as a research probe for adipocyte biology and metabolic disease models.

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Molecular weight
~257-321 g/mol (depending on counter-ion)
Sequence
Not a peptide — small molecule with quinolinium core (C₁₀H₁₁N₂I as iodide salt)
Synonyms
5A1MQ

What is 5-Amino-1MQ?

5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), included in the Peptra Labs research catalog because of its widely used role in metabolic and adipocyte biology research. It is not a peptide. NNMT methylates nicotinamide, depleting cellular NAD+ precursor pools and consuming SAM (S-adenosylmethionine), which has linked NNMT to obesity, fatty liver, and energy expenditure regulation.

Mechanism of action (preclinical evidence)

5-Amino-1MQ is a competitive inhibitor of NNMT with reported IC₅₀ values in the low micromolar range. By blocking NNMT, the compound increases the cellular pool of nicotinamide available for NAD+ salvage and decreases methylation of the nicotinamide pool. In adipocyte and hepatic models, NNMT inhibition has been associated with increased SAM:S-adenosylhomocysteine ratios, altered histone methylation patterns, and changes in lipid metabolism gene expression.

Research applications

  • NNMT enzyme inhibition screens
  • Adipocyte differentiation and lipolysis studies
  • Obesity and metabolic disease preclinical models
  • NAD+/methylation crosstalk research
  • SAM/SAH ratio and histone methylation studies

Storage and handling

Store the lyophilised compound at -20 °C, protected from light and moisture. Standard small-molecule handling applies — fresh stock solutions in DMSO or water depending on counter-ion are typical for assay reproducibility.

Regulatory status

5-Amino-1MQ is an experimental research compound with no approved therapeutic use. Supplied by Peptra Labs for laboratory research only.

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References

  1. Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.
  2. Kraus D, et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262.

Last reviewed: 4 May 2026