DSIP: Delta Sleep-Inducing Peptide Research Guide (2026)
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Introduction (research-only scope)
DSIP, delta sleep-inducing peptide, is a nonapeptide isolated in the 1970s from rabbit brain during sleep research. It is one of the oldest compounds in this catalog and, unusually, one where the published literature openly describes the biology as unresolved. That honesty is the most useful thing a research buyer can know about it.
Research use only. The material described here is a laboratory reagent for in-vitro research by qualified professionals. It is not a medicine, supplement, cosmetic ingredient or veterinary product, is not for human or animal use, and nothing on this page is medical advice or a claim of effect in any person.
What is DSIP?
DSIP (molecular mass 848.83, CAS 62568-57-4) has the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu. It was identified by Monnier and Schoenenberger in Basel from the blood of rabbits in induced sleep states. Peptra Labs supplies it as a lyophilised research reagent, 10 mg per vial.
How the reported mechanism works
No settled receptor
Unlike most peptides in this catalog, DSIP has no established receptor or defined signalling pathway. A 2006 review in the Journal of Neurochemistry is titled, plainly, “a still unresolved riddle”: three decades after isolation, the authors found the reported effects inconsistent across laboratories and the mechanism unidentified.
Transport considerations
Work on peptide transport across the blood-brain barrier, summarised in a 2015 Peptides review, is relevant background for any central-nervous-system study design involving small peptides such as this one.
What the published evidence covers
The evidence base is fragmented: early reports of sleep-related and stress-related effects in animals, followed by decades of inconsistent replication. There are no controlled human trials supporting any use, and no approved product anywhere. A supplier that presents DSIP as an established sleep compound is overstating what exists. In the laboratory it remains a legitimate object of study precisely because the questions are open.
How to verify a DSIP research peptide is real and pure
Two tests answer two different questions: mass spectrometry confirms identity (expected molecular mass 848.83), HPLC quantifies purity. Our specification is at least 98%. Check the batch number printed on your vial against the lab reports archive: where a batch has been tested, its report is published there and links to the testing laboratory’s own verification page. If your batch is not listed yet, ask us for its documentation before use; a “typical” certificate is not evidence for a specific vial. See how to read a certificate of analysis.
Storage and reconstitution
Store the lyophilised material sealed, dry and protected from light at 2 to 8 °C for routine laboratory use, colder for long-term archiving. After reconstitution with bacteriostatic water, keep refrigerated and use within the window your protocol defines; repeated freeze-thaw cycles degrade peptides. General handling for all our reagents is in the peptide storage protocol.
Regulatory status
DSIP is not an authorised medicine in the European Union, the United Kingdom or the United States. It is not named individually on the WADA Prohibited List, but section S0 covers substances without approval for human therapeutic use. Research-grade material supplied here is not a medicine and is for in-vitro laboratory use only. The wider framework, including anti-doping status, is described in the peptide risk profile.
Why labs choose our DSIP
Batch-numbered vials, published reports where a batch has been tested, shipping from an EU warehouse with tracking (no customs inside the EU) and prices shown with VAT included. Product page: DSIP 10 mg. Country-by-country sourcing questions are covered in the buyer guide Buy DSIP in Europe.
References
- Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006. PubMed 16539679
- Banks WA. Peptides and the blood-brain barrier. Peptides. 2015. PubMed 25805003