Tag Archives: semaglutide
Semaglutide in HIV: 108 Participants, 32 Weeks
Semaglutide did not change the trial's measured vascular markers over 32 weeks, while ASCVD risk score and hsCRP differed from placebo.
Semaglutide: SELECT Results by Frailty Status
Semaglutide showed no detectable difference in SELECT cardiovascular results across baseline frailty categories in a new post-hoc analysis.
Tirzepatide: 415 Matched Knee-Arthroplasty Pairs
Tirzepatide and semaglutide showed similar 90- and 180-day postoperative outcomes in 415 matched pairs undergoing knee arthroplasty.
GLP-1 Receptor Agonists: 44 Adolescent Records
GLP-1 receptor agonists were not linked to higher short-term suicidality scores in a small retrospective review of 44 adolescents.
Tirzepatide vs Semaglutide: 8,176 Asthma Pairs
Tirzepatide and semaglutide had similar recorded asthma-exacerbation risk in 8,176 matched pairs, while SABA use differed modestly.
Semaglutide vs Pair-Fed Rats: Splitting Drug From Weight
Semaglutide and pair-fed rats both gained on reproductive measures, but the hormone results separated the drug effect from the weight loss effect.
Semaglutide Extended Lifespan in Mice Treated at 20 Months
Semaglutide started at 20 months extended lifespan in female mice and beat matched calorie restriction on memory, exploration and glucose control.
Semaglutide: 24 Outcomes, 63,215 Adults, One Split
Semaglutide was linked to lower neuropsychiatric event rates in 63,215 adults, and the authors report the association ran independent of weight loss.
Semaglutide in the Spinal Cord: Enkephalin Does the Work
Semaglutide given intrathecally eased burn pain in mice, and blocking enkephalin or the delta-opioid receptor removed the effect, the authors report.
Semaglutide ESSENCE Subgroup: Why 116 Patients Is Too Few
Semaglutide resolved steatohepatitis in 63.1% of 116 Japanese ESSENCE participants. The fibrosis endpoint could not separate at that sample size.