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BPC-157

Body Protection Compound-157

Pentadecapeptide derived from a gastric protective protein, widely studied in preclinical models of tissue repair and gastrointestinal protection.

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Molecular weight
1419.55 Da
Sequence
GEPPPGKPADDAGLV
Synonyms
BPC 157, Bepecin, PL 14736

What is BPC-157?

BPC-157 is a synthetic pentadecapeptide derived from a sequence found within human gastric juice protective protein. In preclinical studies it has been characterised across a wide range of tissue-repair and inflammation models, including tendon, ligament, muscle, gastrointestinal mucosa, and nervous-system contexts. All available evidence is from animal models, isolated organs, or cell-culture systems - no large-scale human trials have evaluated efficacy or long-term safety.

Mechanism of action (preclinical evidence)

Preclinical research has not identified a single high-affinity receptor for BPC-157, which is unusual for a peptide of this clinical research profile. Instead, published mechanistic studies converge on a multi-pathway mode of action centered on the nitric oxide (NO) system, vascular biology, and growth-factor signaling. BPC-157 has been described to interact with the L-arginine/eNOS axis, restoring NO production after vascular injury and modulating endothelial-mediated vasodilation. In tendon-healing models, the peptide has been linked to upregulation of growth hormone receptor (GHR) on tendon fibroblasts and increased VEGF expression, which together would accelerate angiogenesis and matrix deposition at injury sites. There is also published evidence of BPC-157 modulating the dopamine and serotonin systems within the gut-brain axis, consistent with its origin as a fragment of a gastric ulcer-protective protein. Other reported activities include modulation of NF-κB signaling and reduction of inflammatory cytokine release in injury models. The pleiotropic, multi-target nature of these effects is one reason BPC-157 has proven hard to translate into a single defined clinical pathway despite ~30 years of accumulated preclinical literature - the molecule appears to act as a general modulator of injury-response programs rather than as a high-specificity ligand.

Research applications

  • Tendon and ligament regeneration models (rat Achilles tendon transection)
  • Gastric and intestinal mucosal protection (NSAID and ethanol injury)
  • Skin wound healing studies
  • Anastomosis and surgical-injury recovery models
  • Investigation of vascular flow modulation under inflammation

Storage and handling

Lyophilised BPC-157 should be stored at -20 °C, protected from light and moisture. Once reconstituted, follow your laboratory's standard handling protocols; most workflows assume short-term stability at 2-8 °C.

Deep dive

Read the full research guide for BPC-157 to

Mechanism, trial data, sourcing criteria, and verified CoA.

Regulatory status

BPC-157 is not approved by the FDA, EMA, or any major regulator for human use. It is on the WADA Prohibited List (S0). It must be supplied and used strictly for laboratory research only.

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Purity data where applicable · CoA available where applicable · EU shipping

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Frequently asked questions

What is BPC-157 used for in research?+
BPC-157 is studied in preclinical models of tissue repair, particularly gastrointestinal injury (where it was originally isolated), tendon and ligament healing, and angiogenesis. Researchers typically use it in rodent injury models (Achilles tendon transection, gastric ulcer, colitis induction) to study endothelial response, NO signaling, and growth factor expression.
Is BPC-157 approved by the FDA?+
No. BPC-157 is not approved by the FDA, EMA, or any other major regulatory authority as a drug or supplement. It is sold strictly as a research chemical for in-vitro and preclinical laboratory use. It has not completed human clinical trials.
How should BPC-157 be stored?+
Lyophilized BPC-157 should be stored at -20°C in a sealed vial, protected from light. Once reconstituted in sterile water or bacteriostatic water, aliquot to avoid freeze-thaw cycles and use within 28 days at 2-8°C. Batch-level CoA information is available where applicable for purity testing where applicable.
What is the BPC-157 mechanism of action?+
Preclinical studies suggest BPC-157 modulates the nitric oxide (NO) system, upregulates VEGF and other growth factor expression, and supports angiogenesis. It also interacts with the dopamine and serotonin systems in the gut-brain axis. The exact molecular target receptor remains unclear despite ~30 years of published research.
Is BPC-157 banned by WADA?+
Yes. The World Anti-Doping Agency (WADA) added BPC-157 to its prohibited list in 2022 as a non-specified S0 substance (substances not approved for human therapeutic use). Athletes subject to WADA testing must not use BPC-157 in any context.

References

  1. Sikiric P, et al. Brain-gut Axis and Pentadecapeptide BPC 157: Theoretical and Practical Implications. Curr Neuropharmacol. 2016;14(8):857-865.
  2. Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780.
  3. Seiwerth S, et al. BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. Curr Pharm Des. 2018;24(18):1972-1989.

Last reviewed: 4 May 2026