Epithalon
A synthetic tetrapeptide derived from bovine pineal gland extract, investigated as a potential telomerase activator with documented effects on aging biomarkers, melatonin secretion, DNA regulation, and skin cell regeneration. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
Epithalon (Ala-Glu-Asp-Gly) is a short synthetic tetrapeptide first discovered in the late 1980s by Prof. Vladimir Khavinson. As a derivative of epithalamine, it has attracted research interest for telomerase activation and anti-aging properties.
Research Highlights
1. Anti-Aging and Telomerase — Reduced mortality by 52% in fruit flies/rats and 27% in mice. Induced telomerase activity in human somatic cells.
2. DNA and Gene Expression — Interacts with promoter regions of CD5, IL-2, MMP2, and Tram1 genes. Increases interferon gamma expression in aging lymphocytes.
3. Skin Cell Regeneration — Stimulated fibroblast proliferation by 29-45% in young and old rats. Reduces caspase-3 activity.
4. Tumor Growth Modulation — Inhibited spontaneous tumors, prevented metastasis in mice without toxic effects.
5. Melatonin Regulation — Stimulates AANAT and pCREB expression. Restored melatonin production in aged monkeys.
6. Retinal Protection — Improved retinal condition in 90% of retinitis pigmentosa cases.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
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Frequently asked questions
- Each batch is HPLC-MS verified at ≥99% purity. A Certificate of Analysis (COA) including HPLC chromatograms and mass spectrometry data is provided with every shipment.
- Store the lyophilised vial at -20°C, protected from light. Once reconstituted for in-vitro work, follow your laboratory's standard handling and stability protocols. Most reconstituted peptides remain stable at 2-8°C for short-term use.
- No. All Peptra Labs peptides are supplied strictly for laboratory and educational research use only. They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products.
- We ship across the EU and the United Kingdom. Most orders arrive within 2-5 business days. Free shipping on orders over €300.
- Every order includes the product, a Certificate of Analysis (HPLC + MS data, lot number, synthesis date, storage recommendations), and an invoice. Research-use disclaimers are stated on both packaging and documentation.
- Yes. Recent lab reports are available in our Lab Reports section. If you'd like the COA for a specific lot before purchasing, contact us at info@peptralabs.com.
