FOXO4
A synthetic retro-inverso peptide designed to selectively eliminate senescent cells by disrupting the FOXO4-p53 interaction, with demonstrated tissue rejuvenation in preclinical aging models. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
FOXO4-DRI (Proxofim) is a synthetic retro-inverso analogue of FOXO4, incorporating D-amino acids for enhanced proteolytic resistance. It competitively disrupts the FOXO4-p53 interaction that maintains senescent cell viability.
Research Highlights
1. Senescent Cell Elimination โ Restores p53-mediated apoptosis in senescent cells while sparing healthy tissue.
2. Tissue Rejuvenation โ Aged mice showed increased activity, improved cognition, and enhanced fur density. Restored functional integrity in kidneys, liver, and skin.
3. Pathological Scarring โ Promoted apoptosis in keloid fibroblasts and reduced G0/G1 phase proliferation.
4. Insulin Signaling โ FOXO proteins mediate insulin/IGF effects on metabolism and aging.
5. Cardiovascular Protection โ FOXO4 modulation may strengthen cardiac protective mechanisms.
6. Neurodegeneration โ Enhanced protein quality control through proteasome regulation.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
๐ช๐บ EU & UK Shipped โข Free over โฌ300 โข 2-5 Business Days
Frequently asked questions
- Each batch is HPLC-MS verified at โฅ99% purity. A Certificate of Analysis (COA) including HPLC chromatograms and mass spectrometry data is provided with every shipment.
- Store the lyophilised vial at -20ยฐC, protected from light. Once reconstituted for in-vitro work, follow your laboratory's standard handling and stability protocols. Most reconstituted peptides remain stable at 2-8ยฐC for short-term use.
- No. All Peptra Labs peptides are supplied strictly for laboratory and educational research use only. They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products.
- We ship across the EU and the United Kingdom. Most orders arrive within 2-5 business days. Free shipping on orders over โฌ300.
- Every order includes the product, a Certificate of Analysis (HPLC + MS data, lot number, synthesis date, storage recommendations), and an invoice. Research-use disclaimers are stated on both packaging and documentation.
- Yes. Recent lab reports are available in our Lab Reports section. If you'd like the COA for a specific lot before purchasing, contact us at info@peptralabs.com.
