Melanotan 2
A synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) that activates melanocortin receptors, investigated for its roles in melanogenesis, appetite regulation, metabolic modulation, and behavioral responses. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
Melanotan 2 (MT-2) is a cyclic heptapeptide analogue of human α-MSH, originally synthesized at the University of Arizona during the 1980s. It functions as a non-selective melanocortin receptor agonist, binding primarily to MC-1R and MC-4R receptors, with implications for pigmentation, sexual function, appetite control, and metabolic regulation.
Research Highlights
1. Melanocortin Receptor Activation
MT-2 engages multiple melanocortin receptor subtypes. Through MC-1R binding, it stimulates melanin production and skin pigmentation. MC-4R activation influences glucose and cholesterol metabolism, thermogenic responses, and behavioral patterns.
2. Autism Spectrum Research
In a maternal immune activation mouse model, seven-day MT-2 administration improved social behavioral metrics, suggesting potential modulation of oxytocin-related pathways.
3. Appetite and Weight Regulation
MC-4R receptor engagement appears to influence dietary preferences, with studies showing significantly higher fat consumption among MC-4R-deficient individuals.
4. Glycemic Modulation
MT-2 injection into the ventromedial hypothalamus increased glucose uptake in skeletal muscle, brown adipose tissue, and cardiac tissue.
5. Alcohol Intake Reduction
Preclinical studies demonstrated MT-2's capacity to reduce alcohol consumption. When combined with naltrexone, efficacy was enhanced more than sevenfold.
6. Erectile Function Research
In controlled studies, MT-2 induced clinically apparent erections in 8 of 10 participants with psychogenic erectile dysfunction.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
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Frequently asked questions
- Each batch is HPLC-MS verified at ≥99% purity. A Certificate of Analysis (COA) including HPLC chromatograms and mass spectrometry data is provided with every shipment.
- Store the lyophilised vial at -20°C, protected from light. Once reconstituted for in-vitro work, follow your laboratory's standard handling and stability protocols. Most reconstituted peptides remain stable at 2-8°C for short-term use.
- No. All Peptra Labs peptides are supplied strictly for laboratory and educational research use only. They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products.
- We ship across the EU and the United Kingdom. Most orders arrive within 2-5 business days. Free shipping on orders over €300.
- Every order includes the product, a Certificate of Analysis (HPLC + MS data, lot number, synthesis date, storage recommendations), and an invoice. Research-use disclaimers are stated on both packaging and documentation.
- Yes. Recent lab reports are available in our Lab Reports section. If you'd like the COA for a specific lot before purchasing, contact us at info@peptralabs.com.
