Mots-C
A mitochondrial-derived peptide that translocates to the nucleus during metabolic stress, enhancing glucose metabolism, insulin sensitivity, and bone health through AMPK-dependent mechanisms. All presented information is based on scientific publications which can be found at the end of product description below.
Product Specifications
Description
All presented information is based on scientific publications which can be found at the end of product description below.
MOTS-c is a 16-amino-acid mitochondrial-derived peptide discovered around 2012 at USC. It represents a novel form of mitochondrial-nuclear communication, regulating nuclear gene expression during metabolic stress.
Research Highlights
1. Muscle Metabolism — Enhances glucose uptake via AMPK activation independently of insulin pathway.
2. Fat Metabolism — Mitigated obesity and insulin resistance in ovariectomized mice. Reduced sphingolipid and monoacylglycerol metabolism.
3. Insulin Sensitivity — Plasma levels correlate with insulin sensitivity in lean individuals. Enhanced beta-oxidation.
4. Bone Health — Promotes type I collagen synthesis via TGF-β/SMAD pathway and osteogenic differentiation.
5. Longevity — Specific gene variant in Northeast Asian populations associated with exceptional longevity.
6. Cardiovascular — Lower levels correlate with endothelial dysfunction. Pretreatment improved vascular responsiveness.
References available upon request.
The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
Research Use Only: The product is intended for scientific research and development purposes only. Chemical substances shall not be used as a drug, medicine, active substance, medical aid, cosmetic product, a substance for production of a cosmetic product neither for human consumption that is any food or food supplement or otherwise similarly used on humans or animals. Intended only for in-vitro research, such as Receptor-ligand binding studies, Enzyme activity assays, Cell proliferation assays, Cell signaling assays, Epitope mapping, etc.
🇪🇺 EU & UK Shipped • Free over €300 • 2-5 Business Days
Frequently asked questions
- Each batch is HPLC-MS verified at ≥99% purity. A Certificate of Analysis (COA) including HPLC chromatograms and mass spectrometry data is provided with every shipment.
- Store the lyophilised vial at -20°C, protected from light. Once reconstituted for in-vitro work, follow your laboratory's standard handling and stability protocols. Most reconstituted peptides remain stable at 2-8°C for short-term use.
- No. All Peptra Labs peptides are supplied strictly for laboratory and educational research use only. They are not approved for human or veterinary administration, are not evaluated by the FDA or EMA, and must not be used as drugs, supplements, or cosmetic products.
- We ship across the EU and the United Kingdom. Most orders arrive within 2-5 business days. Free shipping on orders over €300.
- Every order includes the product, a Certificate of Analysis (HPLC + MS data, lot number, synthesis date, storage recommendations), and an invoice. Research-use disclaimers are stated on both packaging and documentation.
- Yes. Recent lab reports are available in our Lab Reports section. If you'd like the COA for a specific lot before purchasing, contact us at info@peptralabs.com.
